Brief communication: β-cell function influences dopamine receptor availability
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چکیده
منابع مشابه
Dopamine D2/D3 receptor availability and venturesomeness.
The construct of impulsivity is considered as a major trait of personality. There is growing evidence that the mesolimbic dopamine system plays an important role in the modulation of impulsivity and venturesomeness, the two key components within the impulsivity-construct. The aim of the present study was to explore an association between trait impulsivity measured with self-assessment and the d...
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Understanding the molecular mechanisms that regulate β cell mass and proliferation is important for the treatment of diabetes. Here, we identified domperidone (DPD), a dopamine D2 receptor (DRD2) antagonist that enhances β cell mass. Over time, islet β cell loss occurs in dissociation cultures, and this was inhibited by DPD. DPD increased proliferation and decreased apoptosis of β cells through...
متن کاملBRIEF COMMUNICATION Effects of Dopamine-Receptor Blockade on Self-Stimulation in the Monkey I
MORA, F., E. T. ROLLS, M. J. BURTON AND S. G. SHAW. Effects ofdopamine-receptor blockade on self-stimulation in the monkey. PHARMAC. BIOCHEM. BEHAV. 4(2) 211-216 , 1976. In a do~-response experiment it was shown that intraperitoneal injections of 0.062 mg/kg, and 0.1 mg/kg of the dopamine-receptor blocking agent and neuroleptic spiroperidol severely attenuate self-stimulation in the orbitofront...
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The induction of the vulva of the nematode Caenorhabditis elegans is today recognized as one of the premier systems for studying receptor tyrosine kinase function. More than 40 genes have been identified that modulate intercellular signaling during vulval induction, most have been sequenced, and it is clear that the modus operandi of this signal transduction pathway is highly similar to that of...
متن کاملBrief communication: birth month influences reproductive performance in contemporary women.
BACKGROUND Season of birth has been reported to affect later reproduction in samples of pre-modern women and contemporary men. METHODS To examine whether the effect of birth date is also valid in contemporary women, we investigated the association between birth month and measures of reproductive performance (number of live-born children, % childless individuals) in a representative sample of ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0212738